Title : Phorbol 12-myristate 13-acetate inhibits the antilipolytic action of insulin, probably via the activity of protein kinase Cε.

Pub. Date : 2010 Dec 1

PMID : 20826143






3 Functional Relationships(s)
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1 In this work, the effect of the PKC activator phorbol 12-myristate 13-acetate (PMA) on the antilipolytic action of insulin was determined by analyzing lipolysis induced by a beta3-adrenoceptor agonist CL 316243. Tetradecanoylphorbol Acetate protein kinase C alpha Homo sapiens
2 In this work, the effect of the PKC activator phorbol 12-myristate 13-acetate (PMA) on the antilipolytic action of insulin was determined by analyzing lipolysis induced by a beta3-adrenoceptor agonist CL 316243. Tetradecanoylphorbol Acetate protein kinase C alpha Homo sapiens
3 The pan-PKC inhibitors GF 109203X and chelerythrine inhibited the PMA effect, but the PKCalpha/beta inhibitors Go 6976 and CGP 53353 did not. Tetradecanoylphorbol Acetate protein kinase C alpha Homo sapiens