Title : Design, synthesis and evaluation of difunctionalized 4-hydroxybenzaldehyde derivatives as novel cholinesterase inhibitors.

Pub. Date : 2010 Sep

PMID : 20823602






1 Functional Relationships(s)
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1 The inhibition mechanism revealed that the best active compound 4e displayed a mix-type mode of AChE and BChE by its dual-site interactions with the catalytic triad active center and the peripheral anionic site (PAS) of enzyme. Aminosalicylic Acid acetylcholinesterase (Cartwright blood group) Homo sapiens