Pub. Date : 2010 Dec 1
PMID : 20816942
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells. | Rifaximin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 2 | Rifaximin is a non-absorbable antibiotic endowed with a PXR agonistic activity. | Rifaximin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 3 | In the present study we have investigated whether rifaximin activates PXR in primary human colon epithelial cells and human colon biopsies and assessed whether this antibiotic antagonizes the effect of tumor necrosis factor (TNF)-alpha on expression of PXR and PXR-related genes. | Rifaximin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 4 | Present results demonstrate that primary colon epithelial cells express PXR and that their exposure to rifaximin induces the expression of genes involved in cellular detoxification. | Rifaximin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 5 | Knocking down the expression of PXR in colon epithelial cells by an anti-PXR siRNA, abrogated the counter-regulatory effects exerted by rifaximin on cell exposed to TNFalpha. | Rifaximin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 6 | Knocking down the expression of PXR in colon epithelial cells by an anti-PXR siRNA, abrogated the counter-regulatory effects exerted by rifaximin on cell exposed to TNFalpha. | Rifaximin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 7 | In aggregate, these data illustrate that rifaximin increases the expression of PXR and PXR-regulated genes involved in the metabolism and excretion of xenobiotics and antagonizes the effects of TNFalpha in intestinal epithelial cells and colon biopsies. | Rifaximin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 8 | In aggregate, these data illustrate that rifaximin increases the expression of PXR and PXR-regulated genes involved in the metabolism and excretion of xenobiotics and antagonizes the effects of TNFalpha in intestinal epithelial cells and colon biopsies. | Rifaximin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |