Pub. Date : 2010 Nov 19
PMID : 20816918
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although the activation of GABAergic neurons may be responsible for the chief pharmacologic effect of valproate, recent studies have shown that valproate also suppresses GSK3beta activity. | Valproic Acid | glycogen synthase kinase 3 beta | Mus musculus |
| 2 | While mice treated with morphine developed tolerance, co-administration of valproate attenuated the development of tolerance and impaired the activation of GSK3beta in mice brains. | Valproic Acid | glycogen synthase kinase 3 beta | Mus musculus |
| 3 | These results suggest that the modulation of GSK3beta activity by valproate may be useful and may play a role in the prevention of morphine tolerance. | Valproic Acid | glycogen synthase kinase 3 beta | Mus musculus |