Title : Influence of a single nucleotide polymorphism at the main ribavirin transporter gene on the rapid virological response to pegylated interferon-ribavirin therapy in patients with chronic hepatitis C virus infection.

Pub. Date : 2010 Oct 15

PMID : 20812847






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The equilibrative nucleoside transporter 1 (ENT1) is the main protein involved in ribavirin cellular uptake. Ribavirin solute carrier family 29 member 1 (Augustine blood group) Homo sapiens
2 The equilibrative nucleoside transporter 1 (ENT1) is the main protein involved in ribavirin cellular uptake. Ribavirin solute carrier family 29 member 1 (Augustine blood group) Homo sapiens
3 Polymorphisms at the ENT1 gene may influence ribavirin activity as part of hepatitis C virus (HCV) therapy. Ribavirin solute carrier family 29 member 1 (Augustine blood group) Homo sapiens
4 In summary, a SNP rs760370A G at the ENT1 gene influences the chance of rapid virological response to pegIFN-ribavirin therapy in HIV-infected patients with chronic HCV infection due to HCV genotypes 1 or 4, most likely modulating intracellular ribavirin exposure within hepatocytes. Ribavirin solute carrier family 29 member 1 (Augustine blood group) Homo sapiens
5 In summary, a SNP rs760370A G at the ENT1 gene influences the chance of rapid virological response to pegIFN-ribavirin therapy in HIV-infected patients with chronic HCV infection due to HCV genotypes 1 or 4, most likely modulating intracellular ribavirin exposure within hepatocytes. Ribavirin solute carrier family 29 member 1 (Augustine blood group) Homo sapiens