Pub. Date : 2010 Nov 5
PMID : 20810657
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Using a combination of approaches, we identified the serine residue regulating SHIP1 activity. | Serine | inositol polyphosphate-5-phosphatase D | Homo sapiens |
2 | After mass spectrometric identification of 17 serine and threonine residues on SHIP1 as being phosphorylated by PKA in vitro, studies with truncation mutants of SHIP1 narrowed the phosphorylation site to the catalytic region between residues 400 and 866. | Serine | inositol polyphosphate-5-phosphatase D | Homo sapiens |
3 | These results suggest that activation of SHIP1 by PKA via phosphorylation on Ser(440) is an important regulatory event in hematopoietic cells. | Serine | inositol polyphosphate-5-phosphatase D | Homo sapiens |