Pub. Date : 2010 Nov
PMID : 20810616
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sorafenib inhibits cAMP-dependent ERK activation, cell proliferation, and in vitro cyst growth of human ADPKD cyst epithelial cells. | Cyclic AMP | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | cAMP agonists, including arginine vasopressin, accelerate cyst epithelial cell proliferation through protein kinase A activation of the B-Raf/MEK/extracellular signal-regulated kinase (ERK) signaling pathway. | Cyclic AMP | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | We found that nanomolar concentrations of Sorafenib reduced the basal activity of ERK, inhibited cAMP-dependent activation of B-Raf and MEK/ERK signaling, and caused a concentration-dependent inhibition of cell proliferation induced by cAMP, epidermal growth factor, or the combination of the two agonists. | Cyclic AMP | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | We found that nanomolar concentrations of Sorafenib reduced the basal activity of ERK, inhibited cAMP-dependent activation of B-Raf and MEK/ERK signaling, and caused a concentration-dependent inhibition of cell proliferation induced by cAMP, epidermal growth factor, or the combination of the two agonists. | Cyclic AMP | mitogen-activated protein kinase 1 | Homo sapiens |