Title : Genetic and biochemical characterization of human AP endonuclease 1 mutants deficient in nucleotide incision repair activity.

Pub. Date : 2010 Aug 17

PMID : 20808930






2 Functional Relationships(s)
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1 Expression of the APE1 mutants deficient in the NIR and exonuclease activities reduced the sensitivity of AP endonuclease-deficient E. coli xth nfo strain to an alkylating agent, methylmethanesulfonate, suggesting that our APE1 mutants are able to repair AP sites. Methyl Methanesulfonate apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens
2 Expression of the APE1 mutants deficient in the NIR and exonuclease activities reduced the sensitivity of AP endonuclease-deficient E. coli xth nfo strain to an alkylating agent, methylmethanesulfonate, suggesting that our APE1 mutants are able to repair AP sites. Methyl Methanesulfonate apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens