Title : Propofol modulates agonist-induced transient receptor potential vanilloid subtype-1 receptor desensitization via a protein kinase Cepsilon-dependent pathway in mouse dorsal root ganglion sensory neurons.

Pub. Date : 2010 Oct

PMID : 20808213






3 Functional Relationships(s)
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1 Moreover, the capsaicin-induced desensitization of TRPV1 was markedly attenuated in the presence of propofol in neurons from wild-type mice but not in neurons from PKCepsilon-null mice. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
2 DISCUSSION: Our results indicate that propofol modulates TRPV1 sensitivity to capsaicin and that this most likely occurs through a PKCepsilon-mediated phosphorylation of TRPV1. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
3 DISCUSSION: Our results indicate that propofol modulates TRPV1 sensitivity to capsaicin and that this most likely occurs through a PKCepsilon-mediated phosphorylation of TRPV1. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus