Pub. Date : 2010 Sep 6
PMID : 20805323
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The inhibitory neurotransmitter gamma-amino butyric acid (GABA) is synthesized by two isoforms of the enzyme glutamic acid decarboxylase (GAD): GAD65 and GAD67. | gamma-Aminobutyric Acid | glutamate decarboxylase 1 | Homo sapiens |
| 2 | The inhibitory neurotransmitter gamma-amino butyric acid (GABA) is synthesized by two isoforms of the enzyme glutamic acid decarboxylase (GAD): GAD65 and GAD67. | gamma-Aminobutyric Acid | glutamate decarboxylase 1 | Homo sapiens |
| 3 | The inhibitory neurotransmitter gamma-amino butyric acid (GABA) is synthesized by two isoforms of the enzyme glutamic acid decarboxylase (GAD): GAD65 and GAD67. | gamma-Aminobutyric Acid | glutamate decarboxylase 1 | Homo sapiens |
| 4 | The inhibitory neurotransmitter gamma-amino butyric acid (GABA) is synthesized by two isoforms of the enzyme glutamic acid decarboxylase (GAD): GAD65 and GAD67. | gamma-Aminobutyric Acid | glutamate decarboxylase 1 | Homo sapiens |
| 5 | The inhibitory neurotransmitter gamma-amino butyric acid (GABA) is synthesized by two isoforms of the enzyme glutamic acid decarboxylase (GAD): GAD65 and GAD67. | gamma-Aminobutyric Acid | glutamate decarboxylase 1 | Homo sapiens |
| 6 | The inhibitory neurotransmitter gamma-amino butyric acid (GABA) is synthesized by two isoforms of the enzyme glutamic acid decarboxylase (GAD): GAD65 and GAD67. | gamma-Aminobutyric Acid | glutamate decarboxylase 1 | Homo sapiens |
| 7 | Whereas GAD67 is constitutively active and produces >90% of GABA in the central nervous system, GAD65 is transiently activated and augments GABA levels for rapid modulation of inhibitory neurotransmission. | gamma-Aminobutyric Acid | glutamate decarboxylase 1 | Homo sapiens |
| 8 | Thus two distinct mechanisms target the constitutively active GAD67 to presynaptic clusters to facilitate accumulation of GABA for rapid delivery into synapses. | gamma-Aminobutyric Acid | glutamate decarboxylase 1 | Homo sapiens |