Title : COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function.

Pub. Date : 2010 Aug 30

PMID : 20804550






1 Functional Relationships(s)
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1 Here we investigate if the in vivo immunoregulatory function of MDSC can be reversed by inhibiting prostaglandin synthesis by specific COX-2 inhibition focussing on ROS production by MDSC subtypes. Prostaglandins prostaglandin-endoperoxide synthase 2 Mus musculus