Title : Sigma1-receptor stimulation with fluvoxamine ameliorates transverse aortic constriction-induced myocardial hypertrophy and dysfunction in mice.

Pub. Date : 2010 Nov

PMID : 20802134






2 Functional Relationships(s)
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1 Fluvoxamine treatment significantly restored TAC-induced impaired Akt and endothelial nitric oxide synthase (eNOS) phosphorylation in the LV. Fluvoxamine thymoma viral proto-oncogene 1 Mus musculus
2 Our findings suggest that fluvoxamine protects against TAC-induced cardiac dysfunction via upregulated sigma(1)R expression and stimulation of sigma(1)R-mediated Akt-eNOS signaling in mice. Fluvoxamine thymoma viral proto-oncogene 1 Mus musculus