Title : Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors.

Pub. Date : 2011 Apr 1

PMID : 20801430






1 Functional Relationships(s)
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1 The ability of WY14643 and methOEA to counteract the behavioral, electrophysiological, and neurochemical effects of nicotine was reversed by the PPAR-alpha antagonist 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-a,a-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoic acid (MK886). MK-886 peroxisome proliferator activated receptor alpha Rattus norvegicus