Pub. Date : 2010 Jul 29
PMID : 20798760
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Specifically, 2,7-DAM is not cytotoxic and does not activate the p53 pathway while MC and DMC are cytotoxic and able to activate the p53 pathway. | Mitomycin | tumor protein p53 | Homo sapiens |
| 2 | DMC is more cytotoxic than MC and can also kill p53-deficient cells by inducing degradation of Checkpoint 1 protein, which is not seen with MC treatment of the p53-deficient cells. | Mitomycin | tumor protein p53 | Homo sapiens |