Title : Temperature-dependent lateral and transverse distribution of the epidermal growth factor receptor in A431 plasma membranes.

Pub. Date : 1990 Dec

PMID : 2077131






2 Functional Relationships(s)
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1 Aggregation of the epidermal growth factor receptor was measured by determining the increase in fluorescence energy transfer between receptor-bound fluorescein and tetramethylrhodamine-labeled epidermal growth factor. Fluorescein epidermal growth factor receptor Homo sapiens
2 The extracellular protrusion of the epidermal growth factor receptor was calculated from the magnitude of energy transfer between receptor-bound fluorescein labeled epidermal growth factor and 5-(N-dodecanoylamino)-eosin partitioned into the lipid membrane at 4 and 37 degrees C. No significant change in the distance of closest approach between the N-terminus of epidermal growth factor and the plasma membrane was observed at 4 degrees C (69 +/- 2 A) and 37 degrees C (67 +/- 2 A). Fluorescein epidermal growth factor receptor Homo sapiens