Pub. Date : 2010 Oct
PMID : 20739919
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Accurate prediction of dose-dependent CYP3A4 inhibition by itraconazole and its metabolites from in vitro inhibition data. | Itraconazole | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | The aim of this study was to determine the importance of inhibitory metabolites of itraconazole (ITZ) in in vivo cytochrome P450 (CYP) 3A4 inhibition. | Itraconazole | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | The aim of this study was to determine the importance of inhibitory metabolites of itraconazole (ITZ) in in vivo cytochrome P450 (CYP) 3A4 inhibition. | Itraconazole | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | The metabolites of ITZ were estimated to account for ~50% of the total CYP3A4 inhibition, with the relative contribution increasing with time after ITZ dosing. | Itraconazole | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |