Title : Serotonergic modulation of absence-like seizures in groggy rats: a novel rat model of absence epilepsy.

Pub. Date : 2010

PMID : 20736508






2 Functional Relationships(s)
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1 However, the incidence of SWD was markedly reduced either by the 5-HT(1A) agonist (+-)-8-hydroxy-2-(di-n-propylamino)-tetralin [(+-)8-OH-DPAT] or the 5-HT(2) agonist (+-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane [(+-)DOI]. 8-Hydroxy-2-(di-n-propylamino)tetralin 5-hydroxytryptamine receptor 1A Rattus norvegicus
2 In addition, the inhibitory effects of (+-)8-OH-DPAT and (+-)DOI were reversed by WAY-100135 (5-HT(1A) antagonist) and ritanserin (5-HT(2) antagonist), respectively. 8-Hydroxy-2-(di-n-propylamino)tetralin 5-hydroxytryptamine receptor 1A Rattus norvegicus