Title : Activating stress-activated protein kinase-mediated cell death and inhibiting epidermal growth factor receptor signaling: a promising therapeutic strategy for prostate cancer.

Pub. Date : 2010 Sep

PMID : 20736346






4 Functional Relationships(s)
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1 The goal of this study was to determine whether the natural compound psoralidin alters EGFR-mediated signaling resulting in the inhibition of prostate cancer growth. psoralidin epidermal growth factor receptor Mus musculus
2 Treatment with psoralidin, however, inhibited both constitutive and EGF-induced EGFR activation and simultaneously triggered SAPK signaling, resulting in the induction of apoptosis in AIPC cells. psoralidin epidermal growth factor receptor Mus musculus
3 In addition, psoralidin downregulated EGFR-regulated MAPK signaling and inhibited cell proliferation in AIPC cells. psoralidin epidermal growth factor receptor Mus musculus
4 Our studies suggest that psoralidin may be a potent therapeutic agent that modulates EGFR-mediated key epigenetic events in AIPC. psoralidin epidermal growth factor receptor Mus musculus