Title : Effects of drug interactions on biotransformation and antiplatelet effect of clopidogrel in vitro.

Pub. Date : 2010 Sep

PMID : 20735423






3 Functional Relationships(s)
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1 BACKGROUND AND PURPOSE: The conversion of clopidogrel to its active metabolite, R-130964, is a two-step cytochrome P450 (CYP)-dependent process. Clopidogrel cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 BACKGROUND AND PURPOSE: The conversion of clopidogrel to its active metabolite, R-130964, is a two-step cytochrome P450 (CYP)-dependent process. Clopidogrel cytochrome P450 family 4 subfamily F member 3 Homo sapiens
3 The current investigations were performed to characterize in vitro the effects of different CYP inhibitors on the biotransformation and on the antiplatelet effect of clopidogrel. Clopidogrel cytochrome P450 family 4 subfamily F member 3 Homo sapiens