Pub. Date : 2010 Sep
PMID : 20735423
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | KEY RESULTS: Experiments using HLM or specific CYPs (3A4, 2C19) revealed that at clopidogrel concentrations >10 microM, CYP3A4 was primarily responsible for clopidogrel biotransformation. | Clopidogrel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | KEY RESULTS: Experiments using HLM or specific CYPs (3A4, 2C19) revealed that at clopidogrel concentrations >10 microM, CYP3A4 was primarily responsible for clopidogrel biotransformation. | Clopidogrel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Clarithromycin, another CYP3A4 inhibitor, impaired clopidogrel biotransformation and antiplatelet activity almost as effectively as ketoconazole. | Clopidogrel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | The CYP3A4 substrates atorvastatin and simvastatin both inhibited clopidogrel biotransformation and antiplatelet activity, less potently than ketoconazole. | Clopidogrel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | CONCLUSIONS AND IMPLICATIONS: At clopidogrel concentrations >10 microM, CYP3A4 is mainly responsible for clopidogrel biotransformation, whereas CYP2C19 contributes only at clopidogrel concentrations < or =10 microM. | Clopidogrel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 6 | CONCLUSIONS AND IMPLICATIONS: At clopidogrel concentrations >10 microM, CYP3A4 is mainly responsible for clopidogrel biotransformation, whereas CYP2C19 contributes only at clopidogrel concentrations < or =10 microM. | Clopidogrel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 7 | CONCLUSIONS AND IMPLICATIONS: At clopidogrel concentrations >10 microM, CYP3A4 is mainly responsible for clopidogrel biotransformation, whereas CYP2C19 contributes only at clopidogrel concentrations < or =10 microM. | Clopidogrel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |