Title : The histone deacetylase inhibitor, trichostatin A, inhibits the development of 2,4-dinitrofluorobenzene-induced dermatitis in NC/Nga mice.

Pub. Date : 2010 Oct

PMID : 20728595






2 Functional Relationships(s)
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1 Furthermore, IL-4 production by CD4+ T cells from the lymph nodes of DNFB-treated NC/Nga mice was significantly inhibited by TSA, although levels of IFN-gamma were not. trichostatin A interleukin 4 Mus musculus
2 These findings suggest that TSA suppresses the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing IL-4 production and increasing the T reg cell population. trichostatin A interleukin 4 Mus musculus