Title : Structural determinants of photoreactivity of triplex forming oligonucleotides conjugated to psoralens.

Pub. Date : 2010 Jul 25

PMID : 20725628






1 Functional Relationships(s)
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1 We designed TFO sequences with DNA and 2"-O-methyl RNA backbones conjugated to psoralen by 2-carbon linkers and examined their ability to bind and target damage to model DNA duplexes corresponding to sequences within the human HPRT gene. tfo hypoxanthine phosphoribosyltransferase 1 Homo sapiens