Title : A signal-on electrochemical probe-label-free aptasensor using gold-platinum alloy and stearic acid as enhancers.

Pub. Date : 2010 Oct 15

PMID : 20708400






4 Functional Relationships(s)
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1 Then, Au-PtNPs were electrodeposited onto the electrode surface for the immobilization of aptamer and further hybridization of stearic acid labeled thrombin aptamer (TBA). Gold coagulation factor II, thrombin Homo sapiens
2 In the presence of TB, the TBA bound with TB and released from the self-assembled duplex on the electrode into solution, decreasing the steric hindrance of the aptasensor and facilitating catalytic efficiency of Au-PtNPs in the presence of MB toward H2O2 with an enhanced electrochemical signal. Gold coagulation factor II, thrombin Homo sapiens
3 In the presence of TB, the TBA bound with TB and released from the self-assembled duplex on the electrode into solution, decreasing the steric hindrance of the aptasensor and facilitating catalytic efficiency of Au-PtNPs in the presence of MB toward H2O2 with an enhanced electrochemical signal. Gold coagulation factor II, thrombin Homo sapiens
4 With the enhanced effect of Au-PtNPs/MB modified electrode and stearic acid, a detection limit as low as 3pM for TB was achieved. Gold coagulation factor II, thrombin Homo sapiens