Title : A pretherapy biodistribution and dosimetry study of indium-111-radiolabeled trastuzumab in patients with human epidermal growth factor receptor 2-overexpressing breast cancer.

Pub. Date : 2010 Aug

PMID : 20707718






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1 PURPOSE: The purposes of this study were to evaluate the organ biodistribution, pharmacokinetics, immunogenicity, and tumor uptake of (111)Indium ((111)In)-MxDTPA-trastuzumab in patients with human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancers and to determine whether (90)Y-MxDTPA-trastuzumab should be evaluated in subsequent clinical therapy trials. 2-(4-isothiocyanatobenzyl)-6-methyldiethylenetriaminepentaacetic acid erb-b2 receptor tyrosine kinase 2 Homo sapiens
2 PURPOSE: The purposes of this study were to evaluate the organ biodistribution, pharmacokinetics, immunogenicity, and tumor uptake of (111)Indium ((111)In)-MxDTPA-trastuzumab in patients with human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancers and to determine whether (90)Y-MxDTPA-trastuzumab should be evaluated in subsequent clinical therapy trials. 2-(4-isothiocyanatobenzyl)-6-methyldiethylenetriaminepentaacetic acid erb-b2 receptor tyrosine kinase 2 Homo sapiens