Title : Pharmacokinetic and pharmacodynamic evaluation of sitagliptin plus metformin.

Pub. Date : 2010 Oct

PMID : 20707611






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1 AREAS COVERED IN THIS REVIEW: An extensive literature search was performed to analyze the potential pharmacokinetic (PK) and pharmacodynamic (PD) interactions between metformin (first-line drug for the management of type 2 diabetes) and sitagliptin (first commercialized DPP IV inhibitor). Metformin dipeptidyl peptidase 4 Homo sapiens