Pub. Date : 2010 Aug 15
PMID : 20703083
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment of Tyr-HRas:Cdk4(R24C/R24C) mice with the carcinogen, DMBA/TPA resulted in a further increase in the number of nevi and melanomas developed when compared with Tyr-HRas:Cdk4(+/+) mice. | Tyrosine | Harvey rat sarcoma virus oncogene | Mus musculus |
| 2 | Treatment of Tyr-HRas:Cdk4(R24C/R24C) mice with the carcinogen, DMBA/TPA resulted in a further increase in the number of nevi and melanomas developed when compared with Tyr-HRas:Cdk4(+/+) mice. | Tyrosine | Harvey rat sarcoma virus oncogene | Mus musculus |
| 3 | Treatment of Tyr-HRas:Cdk4(R24C/R24C) mice with the carcinogen, DMBA/TPA resulted in a further increase in the number of nevi and melanomas developed when compared with Tyr-HRas:Cdk4(+/+) mice. | Tyrosine | Harvey rat sarcoma virus oncogene | Mus musculus |
| 4 | In summary, in Tyr-HRas:Cdk4(R24C/R24C) mice, we observed that activated CDK4 cooperates with the oncogenic HRAS(G12V) protein to increase the susceptibility of melanoma development in vivo. | Tyrosine | Harvey rat sarcoma virus oncogene | Mus musculus |
| 5 | In summary, in Tyr-HRas:Cdk4(R24C/R24C) mice, we observed that activated CDK4 cooperates with the oncogenic HRAS(G12V) protein to increase the susceptibility of melanoma development in vivo. | Tyrosine | Harvey rat sarcoma virus oncogene | Mus musculus |