Title : Dual beneficial effects of (-)-epigallocatechin-3-gallate on levodopa methylation and hippocampal neurodegeneration: in vitro and in vivo studies.

Pub. Date : 2010 Aug 5

PMID : 20700524






2 Functional Relationships(s)
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1 Studies have shown that concomitant use of a COMT inhibitor is highly beneficial in controlling the wearing-off phenomenon by improving L-DOPA bioavailability as well as brain entry. Levodopa catechol-O-methyltransferase Homo sapiens
2 EGCG strongly inhibited human liver COMT-mediated O-methylation of L-DOPA in a concentration-dependent manner in vitro, with an average IC50 of 0.36 microM. Levodopa catechol-O-methyltransferase Homo sapiens