Title : An association between BPDE-like DNA adduct levels and CYP1A1 and GSTM1 polymorphisma in pterygium.

Pub. Date : 2010 Apr 8

PMID : 20700368






4 Functional Relationships(s)
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1 An association between BPDE-like DNA adduct levels and CYP1A1 and GSTM1 polymorphisma in pterygium. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide cytochrome P450 family 1 subfamily A member 1 Homo sapiens
2 The relationship between BPDE-like DNA adduct levels and CYP1A1 and GSTM1 gene polymorphisms in pterygium is not clear. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide cytochrome P450 family 1 subfamily A member 1 Homo sapiens
3 Additionally, the risk of BPDE-like DNA adduct formation for patients with CYP1A1 m1/m2 (C/T) andm2/m2 (T/T) was 9.675 fold higher than that of patients with CYP1A1 m1/m1 (C/C) types (p=0.001, 95% Confidence Interval 2.451-38.185). 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide cytochrome P450 family 1 subfamily A member 1 Homo sapiens
4 Additionally, the risk of BPDE-like DNA adduct formation for patients with CYP1A1 m1/m2 (C/T) andm2/m2 (T/T) was 9.675 fold higher than that of patients with CYP1A1 m1/m1 (C/C) types (p=0.001, 95% Confidence Interval 2.451-38.185). 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide cytochrome P450 family 1 subfamily A member 1 Homo sapiens