Title : Reduction of N-hydroxy-sulfonamides, including N-hydroxy-valdecoxib, by the molybdenum-containing enzyme mARC.

Pub. Date : 2010 Nov

PMID : 20699408






3 Functional Relationships(s)
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1 It was synthesized as an analog of the known COX-2 inhibitor valdecoxib (4-[5-methyl-3-phenyl-4-isoxazolyl]-benzenesulfonamide) (Talley et al., 2000). valdecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 It was synthesized as an analog of the known COX-2 inhibitor valdecoxib (4-[5-methyl-3-phenyl-4-isoxazolyl]-benzenesulfonamide) (Talley et al., 2000). valdecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 N-Hydroxy-valdecoxib had low in vitro COX-2 activity but showed significant analgesic activity in vivo and a prolonged therapeutic effect compared with valdecoxib (Erdelyi et al., 2008). valdecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens