Title : Effects of prazosin, clonidine, and propranolol on the elevations in brain reward thresholds and somatic signs associated with nicotine withdrawal in rats.

Pub. Date : 2010 Dec

PMID : 20697697






1 Functional Relationships(s)
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1 RESULTS: In all the experiments, the nicotinic acetylcholine receptor antagonist mecamylamine (3 mg/kg) elevated the brain reward thresholds of the nicotine-treated rats and did not affect those of the control rats. Nicotine cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus