Title : Ghrelin and obestatin promote the allergic action in rat peritoneal mast cells as basic secretagogues.

Pub. Date : 2010 Nov

PMID : 20691233






3 Functional Relationships(s)
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1 In the present study, we investigated the roles of ghrelin and obestatin on mast cell degranulation and found that both ghrelin and obestatin induce the release of histamine from rat peritoneal mast cells. Histamine ghrelin and obestatin prepropeptide Rattus norvegicus
2 In the present study, we investigated the roles of ghrelin and obestatin on mast cell degranulation and found that both ghrelin and obestatin induce the release of histamine from rat peritoneal mast cells. Histamine ghrelin and obestatin prepropeptide Rattus norvegicus
3 Rat peritoneal mast cells and rat basophilic leukemia (RBL-2H3) cells did not express the ghrelin receptor GHSR1a, suggesting that histamine release induced by ghrelin occurs via a receptor-independent mechanism. Histamine ghrelin and obestatin prepropeptide Rattus norvegicus