Pub. Date : 2010 Nov
PMID : 20686488
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To confirm this system, primary rat mesangial cells were treated with hydrogen peroxide (H2O2) to clarify the signal transduction pathway for glomerular angiotensinogen expression. | Hydrogen Peroxide | angiotensinogen | Rattus norvegicus |
| 2 | To confirm this system, primary rat mesangial cells were treated with hydrogen peroxide (H2O2) to clarify the signal transduction pathway for glomerular angiotensinogen expression. | Hydrogen Peroxide | angiotensinogen | Rattus norvegicus |
| 3 | H2O2 induced an increase in angiotensinogen expression in a dose- and time-dependent manner, and the H2O2-induced upregulation of angiotensinogen was suppressed by catalase. | Hydrogen Peroxide | angiotensinogen | Rattus norvegicus |
| 4 | H2O2 induced an increase in angiotensinogen expression in a dose- and time-dependent manner, and the H2O2-induced upregulation of angiotensinogen was suppressed by catalase. | Hydrogen Peroxide | angiotensinogen | Rattus norvegicus |
| 5 | H2O2 induced an increase in angiotensinogen expression in a dose- and time-dependent manner, and the H2O2-induced upregulation of angiotensinogen was suppressed by catalase. | Hydrogen Peroxide | angiotensinogen | Rattus norvegicus |
| 6 | H2O2 induced an increase in angiotensinogen expression in a dose- and time-dependent manner, and the H2O2-induced upregulation of angiotensinogen was suppressed by catalase. | Hydrogen Peroxide | angiotensinogen | Rattus norvegicus |
| 7 | Furthermore, the H2O2-induced upregulation of angiotensinogen was inhibited by a mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitor and a c-Jun N-terminal kinase (JNK) inhibitor, but not inhibited by a p38 MAPK inhibitor. | Hydrogen Peroxide | angiotensinogen | Rattus norvegicus |
| 8 | These data suggest that the majority of angiotensinogen was induced in mesangial cells in glomeruli under pathological conditions such as diabetic nephropathy, and angiotensinogen expression in mesangial cells was mediated by H2O2 and the subsequent activation of extracellular-regulated kinase (ERK)/JNK pathways. | Hydrogen Peroxide | angiotensinogen | Rattus norvegicus |