Title : Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective.

Pub. Date : 2010 Sep

PMID : 20684043






2 Functional Relationships(s)
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1 Interestingly, NMDA treatment induced a higher amount of neurotoxicity in Mix-treated co-cultures than in untreated ones, whereas this extent of neurotoxicity was absent in enriched neuron cultures or in co-cultures with connexin43 knock-out astrocytes. N-Methylaspartate Mix paired-like homeobox Homo sapiens
2 Furthermore, application of connexin43 hemichannel blockers or a synthetic cannabinoid prevented the Mix-induced potentiated NMDA neurotoxicity. N-Methylaspartate Mix paired-like homeobox Homo sapiens