Title : Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase.

Pub. Date : 2010 Oct 8

PMID : 20682772






1 Functional Relationships(s)
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1 In agreement with this, mutation of Ser(696), a known PKA phosphorylation site in RET, enhances SHP2 binding to the receptor and eliminates the effect of forskolin on ligand-induced outgrowth. Serine ret proto-oncogene Homo sapiens