Pub. Date : 2010 Aug
PMID : 20682656
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Therefore, it is not known whether chronically active Ras contributes to thyroid carcinoma cell proliferation, although galectin-3 (Gal-3), which is strongly expressed in thyroid carcinomas but not in benign tumors or normal glands, is known to act as a K-Ras chaperone that stabilizes and drives K-Ras.GTP nanoclustering and signal robustness. | Guanosine Triphosphate | lectin, galactose binding, soluble 3 | Mus musculus |
| 2 | Therefore, it is not known whether chronically active Ras contributes to thyroid carcinoma cell proliferation, although galectin-3 (Gal-3), which is strongly expressed in thyroid carcinomas but not in benign tumors or normal glands, is known to act as a K-Ras chaperone that stabilizes and drives K-Ras.GTP nanoclustering and signal robustness. | Guanosine Triphosphate | lectin, galactose binding, soluble 3 | Mus musculus |
| 3 | Thyroid carcinoma cells strongly expressing Gal-3 showed high levels of K-Ras.GTP expression, and K-Ras.GTP transmitted strong signals to extracellular signal-regulated kinase. | Guanosine Triphosphate | lectin, galactose binding, soluble 3 | Mus musculus |
| 4 | Thyroid carcinoma cells strongly expressing Gal-3 showed high levels of K-Ras.GTP expression, and K-Ras.GTP transmitted strong signals to extracellular signal-regulated kinase. | Guanosine Triphosphate | lectin, galactose binding, soluble 3 | Mus musculus |
| 5 | FTS disrupted interactions between Gal-3 and K.Ras, strongly reduced K-Ras.GTP and phospho-extracellular signal-regulated kinase expression, and enhanced the expression of the cell cycle inhibitor p21 as well as of the thyroid transcription factor 1, which is involved in thyroid cell differentiation. | Guanosine Triphosphate | lectin, galactose binding, soluble 3 | Mus musculus |
| 6 | We conclude that wild-type K-Ras.GTP in association with Gal-3 contributes to thyroid carcinoma malignancy and that Ras inhibition might be a useful treatment strategy against these deadly tumors. | Guanosine Triphosphate | lectin, galactose binding, soluble 3 | Mus musculus |