Title : Cyclophilin A is involved in functional expression of the Na(+)-Ca(2+) exchanger NCX1.

Pub. Date : 2010 Sep 7

PMID : 20681522






3 Functional Relationships(s)
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1 We have shown that treatment of transfected HEK 293 cells expressing the Na(+)-Ca(2+) exchanger NCX1 with CsA results in downregulation of surface expression and transport activity, without any reduction in the total level of cell NCX1 protein [Kimchi-Sarfaty, C., et al. Cyclosporine solute carrier family 8 member A1 Homo sapiens
2 We have shown that treatment of transfected HEK 293 cells expressing the Na(+)-Ca(2+) exchanger NCX1 with CsA results in downregulation of surface expression and transport activity, without any reduction in the total level of cell NCX1 protein [Kimchi-Sarfaty, C., et al. Cyclosporine solute carrier family 8 member A1 Homo sapiens
3 Overexpression of CypA or its R55A mutant, which exhibits a substantially reduced PPIase activity, alleviated the reduction of NCX1 surface expression caused by CsA treatment, suggesting that the PPIase domain was probably not mandatory for NCX1 functional expression. Cyclosporine solute carrier family 8 member A1 Homo sapiens