Title : Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors.

Pub. Date : 2010 Sep 3

PMID : 20677317






2 Functional Relationships(s)
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Protein Name
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1 Most of the synthesized 3-hydroxy-N,N,N-trialkylbenzaminium salts display an AChE affinity in the sub-nanomolar to picomolar range along with excellent AChE/BChE selectivities (SI values up to 138 333). 3-hydroxy-n,n,n-trialkylbenzaminium salts acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Most of the synthesized 3-hydroxy-N,N,N-trialkylbenzaminium salts display an AChE affinity in the sub-nanomolar to picomolar range along with excellent AChE/BChE selectivities (SI values up to 138 333). 3-hydroxy-n,n,n-trialkylbenzaminium salts acetylcholinesterase (Cartwright blood group) Homo sapiens