Pub. Date : 2010 Jul 23
PMID : 20668705
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. | Cholesterol | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. | Cholesterol | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Silencing of the NLRP3 receptor, the crucial component in NLRP3 inflammasome, completely abolished crystal-induced IL-1beta secretion, thus identifying NLRP3 inflammasome as the cholesterol crystal-responsive element in macrophages. | Cholesterol | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | Silencing of the NLRP3 receptor, the crucial component in NLRP3 inflammasome, completely abolished crystal-induced IL-1beta secretion, thus identifying NLRP3 inflammasome as the cholesterol crystal-responsive element in macrophages. | Cholesterol | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | Silencing of the NLRP3 receptor, the crucial component in NLRP3 inflammasome, completely abolished crystal-induced IL-1beta secretion, thus identifying NLRP3 inflammasome as the cholesterol crystal-responsive element in macrophages. | Cholesterol | NLR family pyrin domain containing 3 | Homo sapiens |
| 6 | The crystals were shown to induce leakage of the lysosomal protease cathepsin B into the cytoplasm and inhibition of this enzyme reduced cholesterol crystal-induced IL-1beta secretion, suggesting that NLRP3 inflammasome activation occurred via lysosomal destabilization. | Cholesterol | NLR family pyrin domain containing 3 | Homo sapiens |