Title : The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation.

Pub. Date : 2010 Nov 18

PMID : 20668229






1 Functional Relationships(s)
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1 We show in our current study that the LKB1/AMPK/TSC tumor suppressor axis is functional in AML and can be activated by the biguanide molecule metformin, resulting in a specific inhibition of mammalian target of rapamycin (mTOR) catalytic activity. Biguanides serine/threonine kinase 11 Homo sapiens