Pub. Date : 2012 Jan
PMID : 20665032
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine inhibits tumor necrosis factor-alpha induced IL-6 and IL-8 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis. | Nicotine | tumor necrosis factor | Homo sapiens |
| 2 | Nicotine at concentrations of 0.1-10 muM dose reduced the protein and mRNA expression of IL-6 and IL-8 induced by tumor necrosis factor-alpha (TNFalpha). | Nicotine | tumor necrosis factor | Homo sapiens |
| 3 | Nicotine at concentrations of 0.1-10 muM dose reduced the protein and mRNA expression of IL-6 and IL-8 induced by tumor necrosis factor-alpha (TNFalpha). | Nicotine | tumor necrosis factor | Homo sapiens |
| 4 | In conclusion, nicotine can inhibit the TNFalpha dependant inflammatory pathway in synoviocytes by suppressing the activation of the NF-kappaB pathway. | Nicotine | tumor necrosis factor | Homo sapiens |