Pub. Date : 2010 Sep 1
PMID : 20660715
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we report that capsaicin has a cocarcinogenic effect on 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin carcinogenesis in vivo and is mediated through the epidermal growth factor receptor (EGFR), but not the transient receptor potential vanilloid subfamily member 1 (TRPV1). | Capsaicin | transient receptor potential cation channel, subfamily V, member 1 | Mus musculus |
| 2 | Topical application of capsaicin on the dorsal skin of 7,12-dimetylbenz(a)anthracene-initiated and TPA-promoted TRPV1 wild-type (WT) and TRPV1 knockout (KO) mice induced more and larger skin tumors in TRPV1/KO mice, suggesting a TRPV1-independent mechanism. | Capsaicin | transient receptor potential cation channel, subfamily V, member 1 | Mus musculus |
| 3 | Cyclooxygenase-2 (COX-2) was highly elevated by capsaicin treatment in tumors and murine embryonic fibroblasts from TRPV1/KO mice. | Capsaicin | transient receptor potential cation channel, subfamily V, member 1 | Mus musculus |
| 4 | Inhibitors of EGFR/MEK signaling suppressed TPA/capsaicin-induced COX-2 expression in TRPV1/KO cells, indicating that activation of EGFR and its downstream signaling is involved in COX-2 elevation. | Capsaicin | transient receptor potential cation channel, subfamily V, member 1 | Mus musculus |
| 5 | Specific inhibition of EGFR and TRPV1 indicated that capsaicin-induced ERK activation in A431 cells was dependent on EGFR, but not TRPV1. | Capsaicin | transient receptor potential cation channel, subfamily V, member 1 | Mus musculus |