Title : Human chorionic gonadotropin stimulates theca-interstitial cell proliferation and cell cycle regulatory proteins by a cAMP-dependent activation of AKT/mTORC1 signaling pathway.

Pub. Date : 2010 Sep

PMID : 20660299






2 Functional Relationships(s)
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1 Pharmacologic targeting of mTORC1 with rapamycin also abrogated hCG or FSK-induced phosphorylation of S6K1, rpS6, and eukaryotic initiation factor 4E binding protein 1. Sirolimus chorionic gonadotropin subunit beta 5 Homo sapiens
2 In addition, hCG or FSK-mediated up-regulation of the cell cycle regulatory proteins cyclin-dependent kinase 4, cyclin D3, and proliferating cell nuclear antigen was blocked by rapamycin. Sirolimus chorionic gonadotropin subunit beta 5 Homo sapiens