Title : Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

Pub. Date : 1991 Aug

PMID : 2065663






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 The effect is mediated by the NF-kappa B transcription factor which is potently and rapidly activated by an H2O2 treatment of cells from its inactive cytoplasmic form. Hydrogen Peroxide nuclear factor kappa B subunit 1 Homo sapiens
2 N-acetyl-L-cysteine (NAC), a well characterized antioxidant which counteracts the effects of reactive oxygen intermediates (ROI) in living cells, prevented the activation of NF-kappa B by H2O2. Hydrogen Peroxide nuclear factor kappa B subunit 1 Homo sapiens