Title : Y124 at the peripheral anionic site is important for the reactivation of nerve agent-inhibited acetylcholinesterase by H oximes.

Pub. Date : 2010 Nov 1

PMID : 20655881






1 Functional Relationships(s)
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1 A homology model for wild-type Bo AChE was built using the recently published crystal structure of human AChE and used to generate models of 2-PAM and HI-6 bound to the active-sites of GF- and VR-inhibited Bo AChEs before nucleophilic attack. asoxime chloride acetylcholinesterase (Cartwright blood group) Homo sapiens