Title : Hypoxia and adrenergic function: molecular mechanisms related to Egr-1 and Sp1 activation.

Pub. Date : 2010 Sep 24

PMID : 20654592






4 Functional Relationships(s)
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1 Hypoxia is shown to regulate the stress hormone epinephrine through its biosynthesis by phenylethanolamine N-methyltransferase (PNMT) via PNMT gene activation and transcription factors Egr-1 and Sp1 in adrenal medulla-derived PC12 cells. Epinephrine phenylethanolamine-N-methyltransferase Rattus norvegicus
2 Hypoxia is shown to regulate the stress hormone epinephrine through its biosynthesis by phenylethanolamine N-methyltransferase (PNMT) via PNMT gene activation and transcription factors Egr-1 and Sp1 in adrenal medulla-derived PC12 cells. Epinephrine phenylethanolamine-N-methyltransferase Rattus norvegicus
3 Hypoxia is shown to regulate the stress hormone epinephrine through its biosynthesis by phenylethanolamine N-methyltransferase (PNMT) via PNMT gene activation and transcription factors Egr-1 and Sp1 in adrenal medulla-derived PC12 cells. Epinephrine phenylethanolamine-N-methyltransferase Rattus norvegicus
4 The effects of hypoxia on PNMT and thereby epinephrine may have important ramifications for the stress hormone epinephrine, its ability to regulate behavioral and physiological processes associated with stress and stress-elicited illness. Epinephrine phenylethanolamine-N-methyltransferase Rattus norvegicus