Pub. Date : 2010 Nov 1
PMID : 20654585
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKCalpha enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells. | Cisplatin | glutathione S-transferase pi 1 | Homo sapiens |
| 2 | Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKCalpha enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells. | Cisplatin | glutathione S-transferase pi 1 | Homo sapiens |
| 3 | Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKCalpha enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells. | Cisplatin | glutathione S-transferase pi 1 | Homo sapiens |
| 4 | In this study, we investigated the contribution of this post-translational modification of GSTP1 to tumor cisplatin resistance. | Cisplatin | glutathione S-transferase pi 1 | Homo sapiens |
| 5 | Using two malignant glioma cell lines, MGR1 and MGR3, the ability of PKCalpha-phosphorylated GSTP1 to catalyze the conjugation of cisplatin to glutathione was assessed and correlated with cisplatin sensitivity and cisplatin-induced DNA interstrand cross-links and apoptosis of the cells. | Cisplatin | glutathione S-transferase pi 1 | Homo sapiens |
| 6 | Using two malignant glioma cell lines, MGR1 and MGR3, the ability of PKCalpha-phosphorylated GSTP1 to catalyze the conjugation of cisplatin to glutathione was assessed and correlated with cisplatin sensitivity and cisplatin-induced DNA interstrand cross-links and apoptosis of the cells. | Cisplatin | glutathione S-transferase pi 1 | Homo sapiens |
| 7 | Using two malignant glioma cell lines, MGR1 and MGR3, the ability of PKCalpha-phosphorylated GSTP1 to catalyze the conjugation of cisplatin to glutathione was assessed and correlated with cisplatin sensitivity and cisplatin-induced DNA interstrand cross-links and apoptosis of the cells. | Cisplatin | glutathione S-transferase pi 1 | Homo sapiens |
| 8 | The results showed PKCalpha activation and associated phosphorylation of GSTP1 to correlate significantly with increased glutathionylplatinum formation, decreased DNA interstrand cross-link formation and increased cisplatin resistance. | Cisplatin | glutathione S-transferase pi 1 | Homo sapiens |
| 9 | In both cell lines, siRNA-mediated GSTP1 or PKCalpha transcriptional suppression similarly decreased cisplatin IC(50) and was associated with decreased intracellular levels of glutathionylplatinum metabolite. | Cisplatin | glutathione S-transferase pi 1 | Homo sapiens |
| 10 | Combined inhibition/transcriptional suppression of both PKCalpha and GSTP1 was synergistic in enhancing cisplatin sensitivity. | Cisplatin | glutathione S-transferase pi 1 | Homo sapiens |
| 11 | Although, cisplatin-induced apoptosis was associated with the translocation of Bax to mitochondria, release of cytochrome c and caspase-3/7 activation, the levels of relocalized Bax and cytochrome c were significantly greater following GSTP1 knockdown. | Cisplatin | glutathione S-transferase pi 1 | Homo sapiens |
| 12 | These results support a mechanism of cisplatin resistance mediated by the PKCalpha-dependent serine phosphorylation of GSTP1 and its associated increased cisplatin metabolism, and suggest the potential of simultaneous targeting of GSTP1 and PKCalpha to improve the efficacy of cisplatin therapy. | Cisplatin | glutathione S-transferase pi 1 | Homo sapiens |
| 13 | These results support a mechanism of cisplatin resistance mediated by the PKCalpha-dependent serine phosphorylation of GSTP1 and its associated increased cisplatin metabolism, and suggest the potential of simultaneous targeting of GSTP1 and PKCalpha to improve the efficacy of cisplatin therapy. | Cisplatin | glutathione S-transferase pi 1 | Homo sapiens |
| 14 | These results support a mechanism of cisplatin resistance mediated by the PKCalpha-dependent serine phosphorylation of GSTP1 and its associated increased cisplatin metabolism, and suggest the potential of simultaneous targeting of GSTP1 and PKCalpha to improve the efficacy of cisplatin therapy. | Cisplatin | glutathione S-transferase pi 1 | Homo sapiens |
| 15 | These results support a mechanism of cisplatin resistance mediated by the PKCalpha-dependent serine phosphorylation of GSTP1 and its associated increased cisplatin metabolism, and suggest the potential of simultaneous targeting of GSTP1 and PKCalpha to improve the efficacy of cisplatin therapy. | Cisplatin | glutathione S-transferase pi 1 | Homo sapiens |