Title : The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways.

Pub. Date : 2010 Sep 24

PMID : 20647313






2 Functional Relationships(s)
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1 The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways. Reactive Oxygen Species mitogen-activated protein kinase 8 Homo sapiens
2 In conclusion, our data demonstrate a critical role of NOX3-derived ROS in palmitate-induced insulin resistance in hepatocytes, indicating that NOX3 is the predominant source of palmitate-induced ROS generation and that NOX3-derived ROS may drive palmitate-induced hepatic insulin resistance through JNK and p38(MAPK) pathways. Reactive Oxygen Species mitogen-activated protein kinase 8 Homo sapiens