Title : Ulinastatin-mediated protection against zymosan-induced multiple organ dysfunction in rats.

Pub. Date : 2010 Sep

PMID : 20646933






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1 Ulinastatin treatment significantly decreased the zymosan-induced elevation in serum concentrations of TNF-alpha and sICAM-1 and tissue abundance of TLR mRNA in the liver, kidney and lung, effectively attenuated the development of the polysaccharide-induced biochemical and histological abnormalities and successfully reduced the MODS-associated death. Zymosan tumor necrosis factor Rattus norvegicus