Pub. Date : 2010 Nov 1
PMID : 20646875
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Alcohol suppressed intracellular expression of type I interferons (IFN-alpha/beta) in human hepatocytes. | Alcohols | interferon alpha 1 | Homo sapiens |
| 2 | In addition, alcohol induced the expression of suppressors of cytokine signaling (SOCS-2 and SOCS-3), the key negative regulators of IFN-alpha/beta expression. | Alcohols | interferon alpha 1 | Homo sapiens |
| 3 | These in vitro findings suggest that alcohol, through modulating the expression of key regulators in IFN signaling pathway, inhibits type I IFN-based intracellular innate immunity in hepatocytes, which may contribute to the chronicity of HCV infection and the poor efficacy of IFN-alpha-based therapy. | Alcohols | interferon alpha 1 | Homo sapiens |