Title : Neuroprotection signaling pathway of nerve growth factor and brain-derived neurotrophic factor against staurosporine induced apoptosis in hippocampal H19-7/IGF-IR [corrected].

Pub. Date : 2010 Aug 31

PMID : 20644345






3 Functional Relationships(s)
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1 Here we report that activation of the phosphatidyl inositol 3 kinase (PI3K)/Akt pathway is critical for protection of hippocampal cells from staurosporine (STS) induced apoptosis, characterized by nuclear condensation and activation of the caspase cascade. Staurosporine AKT serine/threonine kinase 1 Homo sapiens
2 Here we report that activation of the phosphatidyl inositol 3 kinase (PI3K)/Akt pathway is critical for protection of hippocampal cells from staurosporine (STS) induced apoptosis, characterized by nuclear condensation and activation of the caspase cascade. Staurosporine AKT serine/threonine kinase 1 Homo sapiens
3 Thus, the survival action of NGF and BDNF against STS-induced neurotoxicity was mediated by the activation of PI3K/Akt signaling through the Trk receptor. Staurosporine AKT serine/threonine kinase 1 Homo sapiens